Flavomaquettes with observer spin label for hyperpolarized EPR
Matthias Elgeti (Leipzig University) / Irene Coin (Leipzig University) / Jens Meiler (Leipzig University)
Goal
Project B07 aims to develop a biological, hypersensitive spin tag for hyperpolarized magnetic resonance spectroscopy and structural biology applications.
Challenge
We will design a small protein “maquette” which, upon light excitation, creates a spin-correlated radical pair whose hyperpolarization can be transferred to other spin systems such as spin labels (EPR) or nuclei (NMR).
Impact
This project will provide new insights into the structural determinants of radical pair formation and decay, polarization transfer in proteins, and how hyperpolarization may be utilized for signal enhancement in magnetic resonance.